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ZSTK474 (PI3K Inhibitor)


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Catalog No.:  B-0307
MW: 417.41
Purity: 99%
CAS: 475110-96-4

Description:  ZSTK474 is a potent inhibitor of all four isoforms of class I PI 3-kinase (α 6.7 nM, β 10.4 nM, γ 11.7 nM, δ 1.8 nM). It binds to the ATP-binding pocket and is more active and less toxic than LY294002. ZSTK474 shows anti-tumor activity against human xenografts (A549, PC-3, WiDr) in mice by arresting cell growth. In addition, it was able to inhibit osteoclast formation and collagen-induced arthritis in a mouse model.

Storage:

-20°C


Options/Sizes Pricing
B-0307-5mg $ 74.00
B-0307-25mg $ 133.00
B-0307-100mg $ 223.00
Additional Information:
Tech Data Sheet - TDS_B-0307_ rev1


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assay and reagents for drug discovery in lipid signaling pathways