INPP4 Activity Kit
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Catalog No.: K-5200 Description: Echelon’s INPP4 Activity Assay is a competitive ELISA which measures the activity of INPP4A and INPP4B. Assay Sensitivity: The assay can measure as little as 25 pmol PI(3)P in a 100 µL detection mixture. |
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INPP4A is a magnesium-independent phosphatase involved in the phosphatidylinositol 3-kinase (PI3K) pathway. INPP4A and its isoenzyme INPP4B hydrolyze the 4-phosphate from the lipid second messenger phosphatidylinositol-3,4-bisphosphate (PI(3,4)P2) to form phosphatidylinositol-3-phosphate (PI(3)P). While little evidence supports its role as a tumor suppressor, INPP4A suppresses glutamate excitotoxicity in the central nervous system and is responsible for the Weeble mouse phenotype. A spontaneous frame shift mutation in the Inpp4a gene is present in the Weeble mouse resulting in selective neuronal loss in the cerebellum resulting, severe ataxia and early death. Storage:Part 1 at 4°C, Part 2 at -20°CRelated Products:INPP4A, active (E-8000)INPP4 substrates: diC8-PI(3,4)P2 (P-3408), diC16-PI(3,4)P2 (P-3416) Malachite Green Phosphatase Assay Kits |
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Additional Information:
Tech Data Sheet - TDS_K-5200 INPP4 ELISA Rev3x |
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