ATX-Red AR-2

Catalog No.:  L-2010
MW: 3331.81
Purity: >90%

Description:  ATX-Red AR-2 is an in vivo imaging probe for visualizing and measuring ATX activity. It is an analog of the autotaxin substrate lysophosphatidylcholine (LPC) and contains a near-infrared fluor (Licor IRDye® 800CW) and quencher (Licor IRDye® QC-1). The design is modeled after FS-3, a fluorogenic ATX substrate that is predictive of ATX activity. In the parent compound, fluorescence is quenched through intramolecular energy transfer, but when autotaxin cleaves ATX-Red AR-2, fluorescence increases. This activation mechanism is specific to autotaxin in vitro and in vivo.

Autotaxin which has lysophospholipase D (lysoPLD) activity, cleaves choline from lysophosphatidylcholine forming lysophosphatidic acid (LPA), a potent mitogen that as been implicated in the pathophysiology of ovarian cancer. LysoPLD/ATX has been demonstrated to increase cell motility, neovascularization, proliferation, and aggressiveness of tumors and is upregulated in numerous cancer lineages (non-small cell lung , glioma, mammary carcinoma, renal cell carcinoma, hepatocellular carcinoma). In addition, dysregulation of the ATX/LPA pathway is central to the pathophysiology of idiopathic pulmonary fibrosis, rheumatoid arthritis, and other inflammatory diseases. Modulation of ATX activity through small-molecules is a currently underexplored target, but one with high potential for novel cancer and anti-inflammatory therapeutics.


-20 °C, protected from light


775/800 nm

Featured in Publications:

Madan, D., C.G. Ferguson, et al. (2013) "Non-Invasive Imaging of Tumors by Monitoring Autotaxin Activity Using an Enzyme-Activated Near-Infrared Fluorogenic Substrate" PLoS One 8(11): e79065

Related Products:

Autotaxin Inhibitor Screening Kits: 96-well (K-4200) and 384-well (K-4200HTS)
Autotaxin Activity Assay (K-4100)
Autotaxin ELISA (K-5600)
Autotaxin Inhibitors: BrP-LPA(L-7416), HA130 (B-0701), S32826 (L-3282), and Thio-ccPA (L-7118)
Autotaxin Enzyme, active (E-4000)

Notice to Purchaser: Echelon Biosciences products are sold for research and development purposes only and are not to be incorporated into products for resale without written permission from Echelon Biosciences. The compound AR-2 and its use in assaying for Lysophospholipase D activity are covered by Echelon Biosciences Inc. US patents 7,485,259 & 7,989,663. The purchase of this product includes a limited, non-transferable immunity from suit under the foregoing patent claims for using only this amount of product for the purchaser's own internal research. For inquiries email

Bulk discounts available, please email for information.

Options/Sizes Pricing
L-2010-10ug $ 84.00
L-2010-50ug $ 411.00
L-2010-100ug $ 649.00
Additional Information:
Tech Data Sheet - L-2010

FAQ - AACR 2013 poster

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assay and reagents for drug discovery in lipid signaling pathways