Products

PF-8380, ATX Inhibitor


Zoom
 
Catalog No.:  B-0702
MW: 478.33
CAS: 1144035-53-9

Description:  PF-8380 is a potent autotaxin (ATX) inhibitor (IC50 2.8 nM/101 nM purified enzyme/whole blood). Excessive activity of ATX is associated with numerous inflammatory conditions, cancers and other disease. Lysophosphatidic acid (LPA) produced by ATX stimulates cell proliferation through G-protein coupled receptorsLPA1-4. PF-8380 is orally bioavailable and effectively inhibits ATX in vivo reducing LPA levels in serum and at the site of inflammation in a rat arthritis model. Can delivered orally with Cat # B-0706 "Oral Formulation Vehicle".

Storage

2-8 °C

References

Gierse, J. et al (2010) "A Novel Autotaxin Inhibitor Reduces Lysophosphatidic Acid Levels in Plasma and the Site of Inflammation"> Journal of Pharmacology and Experimental Therapeutics 334(1):310.

Related Products

Autotaxin Inhibitors: BrP-LPA (L-7416), S32826 (L-3282), HA130 (B-0701)
Autotaxin, active (E-4000)
FS-3, Fluorogenic ATX Substrate (L-2000)
ATX-Red AR-2, ATX Imaging Agent (L-2010)
Autotaxin Activity Assay (
K-4100) & Inhibitor Screening Kits (K-4200 and K-4200HTS)
Oral Formulation Vehicle (B-0706)


Options/Sizes Pricing
B-0702-1mg $ 39.00
B-0702-10mg $ 142.00
Additional Information:
Tech Data Sheet - TDS_B-0702_ Rev_1


Add a specific quantity to your cart    *  


Back to the webstore startpage      Back to the product overview      Your Shopping Cart      Terms of Service


assay and reagents for drug discovery in lipid signaling pathways