Catalog No.:  S-0160
MW: 276.41
Purity: 90%
CAS: 946615-49-2

Description:  The alkyne-modified isoprenoids were developed by the Distefano group at the University of Minnesota as chemical reporters of protein prenylation. The isoprenoids readily penetrate mammalian cells and are used as substrates by prenyltransferases. The pendant alkyne can be derivatized with an azide-containing tag, such as a fluorophore or biotin, via a Cu(I) catalyzed “Click” reaction allowing the prenylated proteins to be identified and quantified.


-20 °C or below


1) A.J. DeGraw, et al. “Evaluation of alkyne-modified isoprenoids as chemical reportersof protein prenylation” (2010) Chem. Biol. Drug Des. 76, 460-47, doi: 10.1111/j.1747-0285.2010.01037.x
2) A. Hosokawa, et al
“Evaluation of an alkyne-containing analogue of farnesyl diphosphate as a dual substrate for protein
prenyltransferases” (2007) Int. J. Pep. Res. Ther. 13, 345-354.DOI 10.1007/s10989-007-9090-3

Options/Sizes Pricing
S-0160-5mg $ 164.00
S-0160-10mg $ 317.00
Additional Information:
Tech Data Sheet - TDS_S-0160_rev1

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assay and reagents for drug discovery in lipid signaling pathways