Sphingosine 1-Phostphate Lyase, active

Catalog No.:  E-5000P

Description:  Truncated sphingosine-1-phosphate lyase (a.a. 62-5686) with N-terminal His tag was expressed in Sf9 cells and purified using nickel-NTA chromatrography.

Sphingosine-1-phosphate lyase (SPL) (E.C. works as a key regulator in the final step of the sphingolipid degradative pathway by irreversibly breaking down the sphingosine-1-phosphate (S1P) to ethanolamine phosphate and hexadecenal. S1P signaling, through its five receptors, is involved in many biological events such as proliferation, inflammation, and apoptosis in cancer and other degenerative diseases.


Store at -80 °C. The enzyme is stable for 6 months from the date of receipt. Avoid repeated freeze thaw cycles.

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Sphingosine 1-phosphate ELISA (K-1900)
Sphingosine Kinase Activity Assay (K-3500)
Sphingosine Kinase Inhibitor Screen (K-4400)

Options/Sizes Pricing
E-5000P-2.5ug $ 110.00
E-5000P-25ug $ 824.00
Additional Information:
Tech Data Sheet - TDS_E-5000P_Rev2

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assay and reagents for drug discovery in lipid signaling pathways