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AS1949490 (SHIP2 Inhibitor)


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Catalog No.:  B-0342
MW: 371.88
CAS: 1203680-76-5

Description:  AS1949490 is a potent, selective SHIP2 inhibitor with IC50 of 0.62 uM for human, which shows less effect on SHIP1 or no effects on some other types of intracellular phosphatases (such as PTEN, synaptojanin, and myotubularin). This compound also activates intracellular insulin signaling pathways in the liver and displays gluconeogensis regulation and antidiabetic effects.

Storage

2-8 °C

References:

A. Suwa, T. Yamanoto, et al. "Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2", British Journal of Pharmacology, 2009,158, 879-88.

Related Products:

3-α-Aminocholestane (3AC, SHIP1 Inhibitor) (B-0341)
SHIP2 active enzyme (E-1000)
5’ PtdIns(3,4,5)P3 Phosphatase Activity Fluorescence Polarization Assay (K-1400)


Options/Sizes Pricing
B-0342-5mg $ 70.00
B-0342-10mg $ 129.00
B-0342-25mg $ 288.00
Additional Information:
Tech Data Sheet - TDS_B-0342 _Rev 1_AS1949490


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assay and reagents for drug discovery in lipid signaling pathways