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ARN14988 (aCDase Inhibitor)


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Catalog No.:  B-0041
MW: 373.83
Purity: 98%
CAS: 1502027-70-4

Acid ceramidase (aCDase) is a lysosomal amidase which hydrolyzes the acyl chain from ceramides forming sphingosine which is subsequently phosphorylated to the bioactive lipid sphingosine 1-phosphate. aCDase is upregulated in many cancer types such as melanoma, prostate, head, neck, and colon cancers. ARN14988 is a potent inhibitor of aCDase in vitro (IC50 = 12 nM) and in A375 melanoma cells (IC50 = 1.5uM). ARN14988 is weakly cytotoxic by itself, but shows a synergystic effect with some common anti-cancer drugs (5-Fluorouracil, vemurafinib, and taxol) in proliferative G361 cells.

Storage

-20 °C or below

References

N. Realini, et al. "Acid Ceramidase in Melanoma: expression, localization, and effects of pharmacological inhibition" J. Biol. Chem., 2016, 291, 2422-2434.


Options/Sizes Pricing
B-0041-5mg $ 75.00
B-0041-10mg $ 125.00
Additional Information:
Tech Data Sheet - TDS_B-0041_rev1


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assay and reagents for drug discovery in lipid signaling pathways