6-O-Palmitoyl-L-ascorbic acid (HAase Inhibitor)

Catalog No.:  B-0601
MW: 414.53
CAS: 137-66-6

Hyaluronidases are a group of enzymes that degrade Hyaluronan (HA), a linear polysaccharide comprised of a repeating disaccharide of N-acetylglucosamine and D-glucuronic acid. HA is involved in many biological processes including structural support, cell migration and tissue turnover. Hyaluronidases are involved in several pathological processes such as bacterial pathogenesis, the spreading of toxins/venoms and cancer progression, making hyaluronidases a potential pharmacological target. 6-O-Palmitoyl-L-ascorbic acid (Vcpal) is a micromolar inhibitor of both bacterial and mammalian hyaluronidases and it is particularily selective for the Streptococcus agalactiae enzyme.


Room temperature or below


1) A. Botzki, et al. “L-Ascorbic Acid 6-Hexadecanoate, a Potent Hyaluronidase Inhibitor: X-ray structure and molecular modeling of enzyme-inhibitor complexes” J. Biol. Chem., 2004, 279, 45990-45997.
2) Spickenreither, M. et al. “Novel 6-O-acylated vitamin C derivatives as hyaluronidase inhibitors with selectivity for bacterial lyases” Bioorg. Med. Chem. Lett., 2006, 16, 5313-5316.

Keywords: Hyaluronidase, Hyal, Hyaluronic acid, Hyaluronan, Vcpal

Options/Sizes Pricing
B-0601-100mg $ 26.00
B-0601-500mg $ 100.00
Additional Information:
Tech Data Sheet - TDS_B-0601_rev1

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assay and reagents for drug discovery in lipid signaling pathways