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1R,2R-B13 (Ceramidase inhibitor)


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Catalog No.:  B-0042
MW: 422.56
Purity: >98%
CAS: 35922-06-6

Ceramides are bioactive sphingolipids which induce apoptosis in cells. Ceramidases, which hydrolyze the fatty acid chain, keep ceramide levels in check and have been proposed as a target for small-molecule inhibitors for anti-cancer therapy. B13 (or D-NMAPPD) is a potent ceramidase inhibitor which causes aopotosis in a number of cell lines including colorectal, HL60, melanoma, and keratinocyes.

Storage

-20 °C or below.

References

1) A. Bielawska, C.M. Linardic, Y. Hannun "Ceramide-mediated biology. Determination of structural and stereospecific requirements through the use of N-acyl-phenylaminoalcohol analogs" J. Biol. Chem., 1992, 267, 18493-7.
2) M. Raisova, G. Goltz, et al. "Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes" FEBS Letters 2002, 516, 47-52.
3) Bhabak, Krishna P.; Kleuser, Burkhard "Effective inhibition of acid and neutral ceramidases by novel B-13 and LCL-464 analogues" Bioorganic & Medicinal Chemistry 2013, 21, 874-882.


Options/Sizes Pricing
B-0042-5mg $ 65.00
B-0042-10mg $ 110.00
B-0042-25mg $ 225.00
Additional Information:
Tech Data Sheet - TDS_B-0042_rev1


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