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K118 (SHIP1 Inhibitor)


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Catalog No.:  B-0344
MW: 311.93
Purity: >95%
CAS: 54156-23-9

SH2-Domain containing inositol 5-phosphatases (SHIP1 & SHIP2) dephosphorylate the 5-position of PI(3,4,5)P3 generating PI(3,4)P2. SHIP2 is ubiquitously expressed while SHIP1 is found in hematolymphoid cells and mesancymal stem cells. K118 is a water soluble SHIP1 inhibitor which does not inhibit SHIP2. Treatment with K118 (10 mg/kg) on obese mice on a high fat diet resulted in reduced body mass and lowered fat content when compared to pre-treatment and non-treated control animals. The treated mice had reduced blood glucose and insulin levels in addition to improved glucose tolerance. K118 treatment also reduced the amount of age-related fat accumulation in mice.

Storage

4 °C or below

References

1) R, Brooks, et al. "Coordinate Expansion of Murine Hematopoietic and Mesenchymal Stem Cell Compartments by SHIPi", Stem Cells, 2015, 33, 848-858. doi:10.1002/stem.1902
2) N. Srivastava "A small-molecule inhibitor of SHIP1 reverses age- and diet-associated obesity and metabolic syndrome" JCI Insight, 2016, 1, e88544 doi:10.1172/jci.insight.88544.


Options/Sizes Pricing
B-0344-5mg $ 78.00
B-0344-25mg $ 325.00
Additional Information:
Tech Data Sheet - TDS_B-0344_rev1


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assay and reagents for drug discovery in lipid signaling pathways