Scientific Background - Anti-infectives

Isoprenoid biosynthetic pathways are essential components in all cells. Isoprenoid compounds are assembled from the single simple precursors, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).

Most bacteria produce IPP through the 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway, whereas fungi and animals use the mevalonate (MVA) pathway. This species segregated dual pathway presents an opportunity for the development of new antibacterial drugs and herbicides

assay and reagents for drug discovery in lipid signaling pathways