Anti-PtdIns(3,4,5)P3 is an IgM monoclonal antibody in ascites.
Subclass: IgM
Source: Mouse
Applications: Immunofluorescence
Specificity: Anti-PtdIns(3,4,5)P3 IgM in ascities has been shown to recognize PtdIns(3,4,5)P3 in murine and human cells. Cross reactivity is 1% orless with other phosphatidylinositol phosphates or lipids.
Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2.
Product keywords: PIP3, PI(3,4,5)P3, PtdIns(3,4,5)P3, IgM, anti-PIP3
