Purified Anti-PtdIns(3,4)P2 antibody
Subtype: IgG3
Source: Mouse
Applications: ELISA, Immunofluorescence, Protein-Lipid Overlay
Phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) is produced in stimulated cells by the action of phosphatidylinositol 3-kinases (PI3Ks) and/or lipid phosphatases (SHIP, TPTE, etc.). PI(3,4)P2 binds the pleckstrin homology (PH)-domain of AKT/PKB leading to cell survival and it also has an important role in podosome formation near focal adhesions.
Featured in Publications
1) Chiang, H. C., L. Wang, et al. (2010). “PI3 kinase signaling is involved in Abeta-induced memory loss in Drosophila.” Proc Natl Acad Sci U S A 107(15): 7060-5.
