PS48 (PDK1 Activator)

PS48 activates phosphoinositide-dependent protein kinase 1 (PDK1) by binding exclusively to PIF-binding pocket rather than the ATP binding site. [Read More...]

PS48 activates phosphoinositide-dependent protein kinase 1 (PDK1) by binding exclusively to PIF-binding pocket rather than the ATP binding site.

References

1) A. Stroba et al. “3,5-Diphenylpent-2-enoic Acids as Allosteric Activators of the Protein Kinase PDK1: Structure-Activity Relationships and Thermodynamic Characterization of Binding as Paradigms for PIF-Binding Pocket-Targeting Compounds”, J. Med. Chem, 2009, 52 (15), 4683-4693

2) L.D. Spate, et al. “PS48 can replace bovine serum albumin in pig embryo culture medium, and improve in vitro embryo development by phosphorylating AKT” Molecular Reproduction & Development 2015, DOI: 10.1002/mrd.22474.

Categories	Biochemical Reagents
Filter	Inhibitor
CAS Number	1180676-32-7
Molecular Formula	C17H15ClO2
Molecular Weight (g/mol)	286.75
Purity	>98%
Storage	4 °C or below
Shipping Temp	Ambient Temperature