NOG is an analogue of alpha ketoglutarate and has been found to be an inhibitor of reactions involving alpha ketoglutarate such as xanthine hydroxylase and alpha ketoglutarate dioxygenase.
References
1) Montero-Moran, G. M., M. Li, et al. (2007). “Purification and characterization of the FeII- and alpha-ketoglutarate-dependent xanthine hydroxylase from Aspergillus nidulans.” Biochemistry 46(18): 5293-304.
2) Kalliri, E., P. K. Grzyska, et al. (2005). “Kinetic and spectroscopic investigation of CoII, NiII, and N-oxalylglycine inhibition of the FeII/alpha-ketoglutarate dioxygenase, TauD.” Biochem Biophys Res Commun 338(1): 191-7.
