Biotinylated Select-HA 500k is a hyaluronic acid (HA) preparation of uniform and narrow size distribution prepared by in vitro synthesis using recombinant Pasteurella multocida hyaluronan synthase. Each HA molecule is end-labeled (reducing terminus) with a single biotin. Biotinylated Select-HA 500k and Select-HA™ is a trademark of Hyalose LLC.
Background
Hyaluronic acid (HA) is a high molecular weight anionic polysaccharide (1,000-10,000 kD) composed of repeating disaccharides and is one of several glycosaminoglycan components of the extracellular matrix of connective tissue. Free HA is taken up by the liver where it is degraded and recycled. Data indicates a relationship between HA levels, local inflammation and severity of many disease such as hepatitis B or C, rheumatoid arthritis, liver fibrosis, etc.
Storage
-20 °C or below. Avoid frequent freeze-thaw, aliquoting is recommended. Avoid contamination with microbes or HA-degrading enzymes.
References
1.Jing, W.; DeAngelis, P. L., Synchronized chemoenzymatic synthesis of monodisperse hyaluronan polymers. J Biol Chem 2004, 279 (40), 42345-9.
