Miltefosine is effective against visceral infections of Leishmanis species through inhibiton of cytochrome c oxidase. In addition, Miltefosine inhibits CTP:phosphocholine cytidylyltransferase and has anti-metastatic effects.
References
1) Rivas, L. & Luque-Ortega, J.R. “Miltefosine (hexadecylphosphocholine) inhibits cytochrome c oxidase in Leishmania donovani promastigotes.” (2007) Antimicrob. Chemother. Agents, 51, 1327-1332.
2) Geilen, C.C., Wieder, T., Reutter, W. “Hexadecylphosphocholine inhibits translocation of CTP: Choline-phosphate cytidylyltransferase in Madin-Darby canine kidney cells.” (1992). J Biol Chem. 267, 6719-6724.
