Thio-ccPA

Thio-ccPA is a stabilized analogue of carbacyclic phosphatidic acid (ccPA). [Read More...]

Thio-ccPA is a stabilized analogue of carbacyclic phosphatidic acid (ccPA). It inhibits the lysoPLD activity of Autotaxin (ATX) and acts as an LPA1/3 receptor antagonist. Thio-ccPA decreases the viability of B16F10, A375, and MeWo melanoma cell lines. Addition of endogenous LPA did not reverse these effects in B16F10 cells. Thio-ccPA decreased the number of pulmonary and non-pulmonary metastases in a B16F10 metastatic melanoma mouse model.

Categories	Lipids
Filter	Lysophospholipid
CAS Number	779333-56-1
Molecular Formula	C22H40NaO4PS
Molecular Weight (g/mol)	454.6
Purity	>95%
Storage	-20 °C or below
Shipping Temp	Gel Ice

Technical Data Sheet

1) Xu, Y., G. Jiang, et al. (2006). “Phosphonothioate and Fluoromethylene Phosphonate Analogues of Cyclic Phosphatidic Acid: Novel Antagonists of Lysophosphatidic Acid Receptors.” Journal of Medicinal Chemistry 49(17): 5309.
2) Altman, M. K., V. Gopal, et al. (2010). “Targeting melanoma growth and viability reveals dualistic functionality of the phosphonothionate analogue of carba cyclic phosphatidic acid.” Mol Cancer 9: 140.

500 ug (L-7118) quantity	500 ug (L-7118)	$132
1 mg (L-7118) quantity	1 mg (L-7118)	$228

Thio-ccPA

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Thio-ccPA

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