PI(3,4,5)P3 diC8 (Phosphatidylinositol 3,4,5-trisphosphate diC8) is a synthetic, purified dioctanoyl PI(3,4,5)P3.

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2.

Product Keywords: Dioctanoyl Phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4,5)P3 (8:0/8:0), PI(3,4,5)P3 C8, or PIP3

Bulk discounts available, please email echelon@echelon-inc.com for information.

Categories	Lipids
Filter	diC8, Phosphoinositides, PI(3,4,5)P3
CAS Number	163563-77-7
Molecular Formula	C25H43Na7O22P4
Molecular Weight (g/mol)	980.42
Purity	>95%
Storage	-20 °C or below
Shipping Temp	Dry ice or gel ice depending on destination

Technical Data Sheet

1. Paternotte, N., J. Zhang, et al. (2005). “SHIP2 interaction with the cytoskeletal protein Vinexin.” FEBS J 272(23): 6052-66.
2. Odriozola, L., G. Singh, et al. (2007). “Regulation of PTEN activity by its carboxyl-terminal autoinhibitory domain.” J Biol Chem 282(32): 23306-15.
3. Hubbard, L. L., C. A. Wilke, et al. (2011). “PTEN Limits Alveolar Macrophage Function Against Pseudomonas aeruginosa Following Bone Marrow Transplantation.” Am J Respir Cell Mol Biol 45(5): 1050-1058.
4. Steidle, E. A., et al. (2016). “A novel inositol pyrophosphate phosphatase in Saccharomyces cerevisiae: Siw14 selectively cleaves the Î²-phosphate from 5-diphosphoinositol pentakisphosphate (5PP-IP5).” J. Biol. Chem. 291: 6772-6783.
5. Somasundaram, R., et al. (2017). “Analysis of SHIP1 expression and activity in Crohnâ€™s disease patients.” PLoS ONE 12(8): e0182308.
6. Patel, V. B., et al. (2018). “PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease.” Nature Communications 9(1): 5390.

100 ug (P-3908) quantity	100 ug (P-3908)	$55
500 ug (P-3908) quantity	500 ug (P-3908)	$234
1 mg (P-3908) quantity	1 mg (P-3908)	$435

PI(3,4,5)P3 diC8

Get in Touch

If you have any questions or would like to learn more about our services, feel free to reach out to us. We’re here to help!

PI(3,4,5)P3 diC8

Related Products

d5-D-myo-Phosphatidylinositol 3,4,5-trisphosphate DiC16

Biotinylated Anti-PtdIns(3,4,5)P3 IgM

3C-PtdIns(3,4,5)P3, diC8

Lipid 10

Get in Touch

If you have any questions or would like to learn more about our services, feel free to reach out to us. We’re here to help!

Login

Register