PI(3,4,5)P3 (D-myo-Phosphatidylinositol 3,4,5-trisphosphate) 17:0/16:0 is a synthetic PI(3,4,5)P3 analog with an unnatural C17 acyl chain at the sn-1 position.
Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2. Phosphatidylinositol 3,4,5-trisphosphate 17:0/16:0 is a synthetic PI(3,4,5)P3 analog with an unnatural C17 acyl chain at the sn-1 position.
Product Keywords: Dipalmitoyl Phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4,5)P3, PI(3,4,5)P3 (17:0/16:0), or PIP3
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