Sphingosine 1-phosphate (S1P) is a bioactive lysophospholipid formed by phosphorylation of sphingosine by sphingosine kinases. S1P binds to five G-protein coupled receptors designated S1P1-5 leading to cell proliferation, motility, and has a role in regulation cell shape. In addition, S1P acts as an intracellular mediator in a receptor-independent manner regulating cell survival and Ca2+ homeostasis. Sphingosine 1-phosphate TAMRA (S1P-TAMRA) is a S1P analog with natural erythro stereochemistry labeled at the terminus of the alkyl chain with tetramethylrhodamine.
Excitation/Emission: 555/580 nm
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Featured in Publications
1) Kashem, M. A., et al. (2016). “A High-Throughput Genetic Complementation Assay in Yeast Cells Identified Selective Inhibitors of Sphingosine Kinase 1 Not Found Using a Cell-Free Enzyme Assay.” Assay Drug Dev Technol 14(1): 36-49.
2) Nagatake, T., et al. (2020). “Selective expression of claudin-5 in thymic endothelial cells regulates the blood–thymus barrier and T-cell export.” International Immunology 33(3): 171-182.
3) Pei, G., et al. (2021). “Cellular stress promotes NOD1/2-dependent inflammation via the endogenous metabolite sphingosine-1-phosphate.” The EMBO Journal: e106272.
4) Chahar, K. R., et al. (2021). “Sphingosine kinases negatively regulate the expression of matrix metalloproteases (MMP1 and MMP3) and their inhibitor TIMP3 genes via sphingosine 1-phosphate in extravillous trophoblasts.” Reproductive Medicine and Biology 20(3): 267-276.
