FTT5 (Echelon Cat#: N-1115) is an analog of TT3 (Echelon Cat#: N-1113). FTT5 lipid nanomaterials (LNPs) displayed two-fold potency in the delivery efficiency of mRNA to the liver, compared to TT3 LNPs. FTT5 LNPs efficiently delivered long mRNAs, such as human factor VIII (hFVIII) mRNA (~4.5 kb) for expression of hFVIII protein in hemophilia A mice in vivo.
Product No: N-1115
