Lipid M is an ionizable lipid used to form lipid nanoparticles for delivering RNA. LNPs formulated with Lipid M delivered luciferase mRNA in mice resulting in higher protein expression compared to the benchmark lipid DLin-MC3-DMA. Lipid M LNPs delivering IgG mRNA showed prolonged expression compared to MC3 in non-human primates after intramuscular injection. LNPs formulated with Lipid M were able deliver EGFP and ciliary neurotrophic factor (CNTF) mRNA to retinal pigment epithelium (RPE) cells after intravitreal injection. Acute inflammation was not observed up to 6 hours post injection.

Categories	Lipids
Filter	Ionizable/Cationic Lipids
CAS Number	2089251-57-8
Molecular Formula	C44H87NO5
Molecular Weight (g/mol)	710.18
Purity	>95%
Storage	-20 °C or below
Shipping Temp	Ambient Temperature

Technical Data Sheet

1) Hassett KJ, Benenato KE, et al. Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines. Mol Ther Nucleic Acids. 2019 Apr 15;15:1-11. doi: 10.1016/j.omtn.2019.01.013.
2) Cheri Z. Chambers, Gillian L. et al. Lipid Nanoparticle-Mediated Delivery of mRNA Into the Mouse and Human Retina and Other Ocular Tissues. Trans. Vis. Sci. Tech. 2024;13(7):7. doi: 10.1167/tvst.13.7.7.

5 mg (N-1103) quantity	5 mg (N-1103)	$175
10 mg (N-1103) quantity	10 mg (N-1103)	$295
25 mg (N-1103) quantity	25 mg (N-1103)	$525

Lipid M

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Lipid M

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