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Intracellular Delivery of Phosphoinositides: Expanded Applications

In the realm of biological research, the efficient delivery of molecules into cells is a fundamental yet often challenging task. S

5 minute read
By Paul Neilsen
October 28

Blog
504B3 LPA antibody has higher affinity for species of lysophosphatidic acid over all other tested lipids - Echelon Biosciences

How specific is the LPA Assay Kit II?

In this blog post, we will present the specificity data for the Lysophosphatidic Acid (LPA) Assay Kit II (cat# K-2800S). This ELIS

6 minute read
By Angie Branch
August 27

Blog
Schematic of PI4P synthesis by PI4-kinase - Echelon Biosciences

Why care about PI4-Kinase?

PI4-kinase, or phosphatidylinositol 4-kinase (PI4K), is an enzyme involved in the synthesis of phosphatidylinositol 4-phosphate (P

6 minute read
By Angie Branch
November 30

Blog
LNP Schematic - Echelon Biosciences Example of lipid nanoparticle with four lipid types and RNA as the cargo.

Lipid Nanoparticles for RNA Delivery

Genetic therapies have now been pursued for several decades and close to a dozen DNA-based gene therapies have gained regulatory a

6 minute read
By Colin Ferguson
September 5

Blog

Semi-quantitative PEth ELISA may simplify clinical analysis of alcohol consumption

Coauthored with Jeff Johnson and Melissa Burback According to a May 2022 report from the World Health Organization (WHO), 3 millio

4 minute read
By Paul Neilsen
August 8

Blog
PIKfyve structure (adapted from Lees and Li et al. 2020; PDB entry 7K2V). Model shows cryo-EM densities for predicted PIKfyve's CCT (yellow) and kinase (blue) domains. - Echelon Biosciences

PIKfyve therapeutic opportunities

PIKfyve, also known as PIP5K3, is a lipid kinase that synthesizes two rare phosphoinositides, PI(5)P and PI(3,5)P2 (Figure 1). The

5 minute read
By Cameron Day
February 13

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