CAS Number: 147600-40-6
Molecular Weight: 384.27
Salt Form: TFA
Purity: >90%
Sequence (3-letter): Ac-Leu-Val-Lys-CHO
Sequence (1-letter): Ac-LVK-CHO
Storage: -20 °C or below
Ac-Leu-Val-Lys-CHO is a potent reversible peptidyl aldehyde inhibitor of Cathepsin B (IC₅₀ = 4 nM). Cathepsin B is a lysosomal cysteine protease with a role in intracellular protein degradation. Cathepsin B crosses the blood-brain barrier and elevated levels are implicated in many neurological maladies including traumatic brain injury, epilepsy, and Alzheimer’s disease.
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