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Schematic of PI4P synthesis by PI4-kinase - Echelon Biosciences

Why you should care about PI4-Kinase activity

PI4-kinase, or phosphatidylinositol 4-kinase (PI4K), is an enzyme involved in the synthesis of phosphatidylinositol 4-phosphate (P

6 minute read
By Angie Branch
November 30

Blog
LNP Schematic - Echelon Biosciences Example of lipid nanoparticle with four lipid types and RNA as the cargo.

Lipid Nanoparticles for RNA Delivery

Genetic therapies have now been pursued for several decades and close to a dozen DNA-based gene therapies have gained regulatory a

6 minute read
By Colin Ferguson
September 5

Blog

Semi-quantitative PEth ELISA holds promise for simplifying clinical analysis of alcohol consumption

Coauthored with Jeff Johnson and Melissa Burback According to a May 2022 report from the World Health Organization (WHO), 3 millio

4 minute read
By Paul Neilsen
August 8

Blog

Methacrylated Hyaluronic Acid: Benefits and Applications

Coauthored with Patrick McDaniel from HTL From dermal fillers to eye drops and from drug delivery to tissue engineering, hyaluroni

4 minute read
By Fok Vun Chan
June 29

Blog
PIKfyve structure (adapted from Lees and Li et al. 2020; PDB entry 7K2V). Model shows cryo-EM densities for predicted PIKfyve's CCT (yellow) and kinase (blue) domains. - Echelon Biosciences

PIKfyve: function and inhibition as therapeutic opportunities

PIKfyve, also known as PIP5K3, is a lipid kinase that synthesizes two rare phosphoinositides, PI(5)P and PI(3,5)P2 (Figure 1). The

5 minute read
By Cameron Day
February 13

Blog

Identifying lipid-protein interactions with Lipid Beads and LC/MS

Lipid Coated Beads are lipid-protein interaction tools originally conceived around eight phosphatidylinositol phosphate coatings t

4 minute read
By Jeff Johnson
March 30

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