Name: D-sn-1-O-oleoyl-2-O-methylglyceryl-3-phosphothionate (2R-OMPT)
SKU: L-9318
Price: 395 USD
Availability: InStock

D-sn-1-O-oleoyl-2-O-methylglyceryl-3-phosphothionate (2R-OMPT)

2R-OMPT is a metabolically-stabilized analog of Lysophosphatidic Acid (LPA) which acts as potent agonist for the LPA3 receptor. [Read More...]

2R-OMPT is a metabolically-stabilized analog of Lysophosphatidic Acid (LPA) which acts as potent agonist for the LPA3 receptor. Of the two enantiomers, (2S)-OMPT is more potent than (2R)-OMPT showing 5-20 fold more activity in calcium release from LPA3-transfected Sf9 and rat hepatoma Rh7777 cells. (2S)-OMPT is also more potent in inducing calcium release, IL-6 production, and MAPK and Akt phosporylation in OVCAR3 cells.

Categories	Biochemical Reagents
Filter	Agonist, Lysophosphatidic Acid, Lysophospholipid
CAS Number	645408-60-2
Molecular Formula	C22H43O6PS
Molecular Weight (g/mol)	466.61
Purity	>95%
Storage	-20 °C or below
Shipping Temp	Gel Ice

Technical Data Sheet

1) Qian, L., Y. Xu, et al. (2003). “Enantioselective responses to a phosphorothioate analogue of lysophosphatidic acid with LPA3 receptor-selective agonist activity.” J Med Chem 46(26): 5575-8.
2) Altman, M. K., V. Gopal, et al. (2010). “Targeting melanoma growth and viability reveals dualistic functionality of the phosphonothionate analogue of carba cyclic phosphatidic acid.” Mol Cancer 9: 140.

D-sn-1-O-oleoyl-2-O-methylglyceryl-3-phosphothionate (2R-OMPT)

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D-sn-1-O-oleoyl-2-O-methylglyceryl-3-phosphothionate (2R-OMPT)

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