CAS Number: 219137-97-0
Molecular Weight: 673.72
Salt Form: N/A
Purity: >95%
Sequence (3-letter): Ac-Val-Glu-Ile-Asp-AMC
Sequence (1-letter): Ac-VEID-AMC
Storage: -20 °C or below
Solubility: DMSO, phosphate buffer pH 7.5
Ac-VEID-AMC is a fluorogenic substrate for caspase 6 (Mch-2α), a member of the cysteine-aspartate protease family, which play a central role in the execution-phase of apoptosis. The excitation/emission maximum of AMC is 340-360/440-460 nm, respectively. Ac-VEID-AMC is based on lamin A site of cleavage.
References
1. Benford, H.L. et al. (2001) “Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro” 28 (5): 465–473.
2. Rouaux, C. e al. (2003) “Critical loss of CBP/p300 histone acetylase activity by caspase-6 during neurodegeneration” EMBO J. 22 (24): 6537–6549.
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