Molecular Weight: 881.42
Salt Form: HCl
Purity: >96%
Sequence (3-letter): Bz-Arg-Gly-Phe-Phe-Pro-4MbNA
Sequence (1-letter): Bz-RGFFP-4MbNA
Storage: -20 °C or below
Bz-Arg-Gly-Phe-Phe-Pro-4MbNA is a fluorogenic substrate for Cathepsin D. Cathepsin D is a lysosomal aspartyl protease whose role is to degrade and activate intracellular proteins including hormones, enzyme precursors, and growth factors. Over expression in tumors stimulates metastasis and considered a marker of poor prognosis in breast cancer.
Activity is quantified by release of free fluorescent 4-Methoxy-β-naphthylamine (4MβNA) which excites at 335-350 nm and emits at 410-440 nm.
![Angiotensin I [Asn1,Val5], goosefish - Echelon Biosciences](https://www.echelon-inc.com/wp-content/uploads/2019/11/137-39.jpg)