Product Number: N-1012
Ionizable lipids in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based therapeutics. [Read More...]
Ionizable lipids in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based therapeutics. cKK-E12 has been used to deliver siRNA in mice, rats, and primates (ED50 = 0.002, 0.01, & 0.3 mg/kg respectively). It shows low toxicity and is selective for liver parenchymal cells over liver, heart, lung, and kidney endothelial cells. This product is for research use only and not for human use.
| Categories | Lipids |
|---|---|
| Filter | Ionizable/Cationic Lipids |
| CAS Number | 1432494-65-9 |
| Molecular Formula | C60H120N4O6 |
| Molecular Weight (g/mol) | 993.64 |
| Purity | 0.95 |
| Storage | 4 °C or below |
| Shipping Temp | Gel Ice |
1) Y. Dong, et al., “Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates” PNAS, 111(11) 3955 (2014) DOI: 10.1073/pnas.1322937111
2) M.A. Oberli, A.M.Reichmuth, et al. “Lipid Nanoparticle Assisted mRNA Delivery for Potent CancerImmunotherapy” Nano Lett, 17, 1326 (2017). DOI: 10.1021/acs.nanolett.6b03329
3) Miao, L., Lin, J., Huang, Y. et al. Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver. Nat Commun 11, 2424 (2020). DOI: 10.1038/s41467-020-16248-y
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