SKI-II is a commonly used inhibitor of both sphingosine kinase I (SPHK1) and 2 (SPHK2). Recently it has been shown to inhibit dihydroceramide desaturase (Des1) which Aurelio et al. suggest is actually responsible for its anti-proliferative activity, not SPHK inhibition. Compound 34 is an analog of SKI-II and is a selective Des1 inhibitor which shows no activity against either SPHK1 or SPHK2. 34 inhibits PC3 cell growth (GIC50 = 0.34 μM) but some of this may be due to inhibition of another target
Product Number: B-0027
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B-0027
DES1 Inhibitor
SKI-II is a commonly used inhibitor of both sphingosine kinase I (SPHK1) and 2 (SPHK2). [Read More...]
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