CAS Number: 117399-94-7
Molecular Weight: 2491.9
Salt Form: TFA
Purity: >96%
Sequence (3-letter): Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH (Cys1-15, Cys3-11)
Sequence (1-letter): CSCSSLMDKECVYFCHLDIIW-OH (C1-15, C3-11)
Storage: -20 °C or below
Solubility: >1 mg/ml in water
Endothelin-1 is one of three isoforms of human endothelin (ET-1). It is a potent vasoconstrictor that is expressed by many cell types, with the vascular endothelium being most prominent. ET-1 is also produced by many tissues, including kidney, brain and lung among others. Antagonists of ET-1 receptors are used to treat pulmonary hypertension by inhibiting pulmonary vascular constriction thereby decreasing pulmonary vascular resistance.
References
1. Sanchez, O. et al. (2006) “Immunosuppressive therapy in connective tissue diseases-associated pulmonary arterial hypertension” Chest 130 (1): 182-189
2. Mubarak, K.K. (2010) “A review of prostaglandin analogs in the management of patients with pulmonary arterial hypertension” Respir. Med. 104 (1): 9-21
3.Fellner, S.K. and Arendshorst, W.J. (2004) “Endothelin A and B receptors of preglomerular vascular smooth muscle cells” Kidney International, 65: 1810–1817.
