CAS Number: 153049-49-1
Molecular Weight: 950.15
Salt Form: Na+
Purity: >96%
Sequence (3-letter): Ac-D-Bhg-Leu-Asp-Ile-Ile-Trp-OH
Sequence (1-letter): Ac-(D-Bhg)LDIIW-OH
Storage: -20 °C or below
Solubility: water, PBS and DMSO 1 mg/ml
D-Bhg = D-5H-Dibenzo[a,d]cycloheptene-5-acetic acid
ET Antagonist PD 145065 is used as an endothelin-A/endothelin-B (ETA/ETB) receptor antagonist. PD 145065 is also a growth factor that binds to G protein-coupled receptors and serves as a useful model to study mitogenic signal transduction by vasoactive peptides.
References
1. Kanagy, N.L. et al. (2001) “Role of Endothelin in Intermittent Hypoxia-Induced Hypertension” 37 (2 Pt 2): 511-5.
2. Bourque, S.L. et al (2012) “Role of endothelin-1 in the hyper-responsiveness to nitrovasodilators following acute NOS inhibition” Br. J. Pharmacol. 165 (6): 1992-1999.
3. Dobrowolski, L. (2003) “Cardiovascular and renal effects of endothelin receptor blockade with PD 145065 and interaction with urodilatin” Acta Physiol. Scand. 159 (1): 7-13.
