Farnesyl thiolodiphosphate (FSPP) is an analog of FPP in which the non-bridging oxygen has been replaced by sulfur resulting in a less-reactive compound.
Provided as the tris-ammonium salt
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Publications
Powered by Bioz1. Phan, R. M. and C. D. Poulter (2001). “Synthesis of (S)-Isoprenoid Thiodiphosphates as Substrates and Inhibitors.” The Journal of Organic Chemistry 66(20): 6705.
2. Hast, M. A., C. B. Nichols, et al. (2011). “Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens.” Journal of Biological Chemistry 286(40): 35149-35162.
3. Lee, L. V., B. Granda, et al. (2010). “Biophysical Investigation of the Mode of Inhibition of Tetramic Acids, the Allosteric Inhibitors of Undecaprenyl Pyrophosphate Synthase.” Biochemistry 49(25): 5366.
4. Kirby, J., et al. (2016). “Engineering a functional 1-deoxy-D-xylulose 5-phosphate (DXP) pathway in Saccharomyces cerevisiae.” Metabolic Engineering 38: 494-503.
5. Catania, T. M., et al. (2018). “Silencing amorpha-4,11-diene synthase Genes in Artemisia annua Leads to FPP Accumulation.” Frontiers in Plant Science 9(547).
