Inositol phosphates are important signaling molecules involved in numerous cellular functions. Inositol 1,4,5-trisphosphate (Ins(1,4,5)P3), aka IP3, is a second messenger produced by phospholipase C catalyzed hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2). IP3 binds to the IP3-receptor on the endoplasmic reticulum causing calcium to be released through the opening of a tetrameric ion channel. IP3 is rapidly metabolized by a specific series of inositol phosphatases and kinases.
Powered by BiozReferences
“Phosphatidylinositol and inositol phosphate metabolism.” J. Cell Sci. 2001, 114, 2207-8.
Keywords: D-myo-Inositol 1,4,5-trisphosphate, Ins(1,4,5)P3, I(1,4,5)P3, or IP3
Bulk discounts available, please email echelon@echelon-inc.com for information.
