Lipid M is an ionizable lipid used to form lipid nanoparticles for delivering RNA. LNPs formulated with Lipid M delivered luciferase mRNA in mice resulting in higher protein expression compared to the benchmark lipid DLin-MC3-DMA. Lipid M LNPs delivering IgG mRNA showed prolonged expression compared to MC3 in non-human primates after intramuscular injection. LNPs formulated with Lipid M were able deliver EGFP and ciliary neurotrophic factor (CNTF) mRNA to retinal pigment epithelium (RPE) cells after intravitreal injection. Acute inflammation was not observed up to 6 hours post injection.
Product No: N-1103
N-1103
Lipid M
Lipid M is an ionizable lipid used to form lipid nanoparticles for delivering RNA. [Read More...]
