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nanoHA™ is a hyaluronic acid (HA) oligomer prepared by chemoenzymatic synthesis with immobilized enzyme reactors. The reducing end contains N-acetylglucosamine. nanoHA™ is a trademark of Hyalose LLC.
Background
Hyaluronic acid (HA) is a high molecular weight anionic polysaccharide (1,000-10,000 kD) composed of repeating disaccharides and is one of several glycosaminoglycan components of the extracellular matrix of connective tissue. Free HA is taken up by the liver where it is degraded and recycled. Data indicates a relationship between HA levels, local inflammation and severity of many disease such as hepatitis B or C, rheumatoid arthritis, liver fibrosis, etc.
Storage
-20 °C or below. Avoid frequent freeze-thaw, aliquoting is recommended. Avoid contamination with microbes or HA-degrading enzymes.
References
1. DeAngelis, P. L.; Oatman, L. C.; Gay, D. F., Rapid chemoenzymatic synthesis of monodisperse hyaluronan oligosaccharides with immobilized enzyme reactors. J Biol Chem 2003, 278 (37), 35199-203.
