CAS Number: 58889-67-1
Molecular Weight: 1671.9
Salt Form: TFA
Purity: >96%
Sequence (3-letter): Glp-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH (Glp = Pyroglutamic acid)
Sequence (1-letter): (Glp)LYENKPRRPYIL-OH
Storage: -20 °C or below
Solubility: water (0.7 mg/mL)
Neurotensin (NT) is a brain and gastrointestinal peptide with many central and peripheral functions. It is a neurotransmitter-like hypothalamic peptide that lowers blood pressure, increases vascular permeability, and increases blood levels of glucagon, glucose, growth hormone, and prolactin in rats. NT acts as modulator of dopamine transmission and exerts potent hypothermic and analgesic effects. Peripherally, NT acts as a paracrine and endocrine modulator of the digestive tract and cardiovascular system
References
1. Carraway, R. and Leeman, S.E. (1973) “The Isolation of a New Hypotensive Peptide, Neurotensin, from Bovine Hypothalami” J. Biol. Chem. 248: 6854-6861.
2. White, J.F. et al. (2012) “Structure of the agonist-bound neurotensin receptor” Nature 490 (7421): 508-513.
3. Tanaka, K., Masu, M. and Nakanishi, S. (1990) “Structure and functional expression of the cloned rat neurotensin receptor” Neuron 4 (6,): 847–854.
